Metastasis Suppressor Genes

Tumour suppressor genes and risk of metastasis in ovarian cancer.

The silent onset of ovarian cancer often leads to metastatic spread before diagnosis can be made. The cause remains unknown, but molecular studies are beginning to reveal some mechanisms. Inactivation of tumour suppressor genes is thought to be responsible for initiating many forms of cancer. Studies of allele loss indicate areas of genome where inactivation may occur. We recently examined the ...

DNA methylation of tumor suppressor and metastasis suppressor genes in circulating tumor cells.

BACKGROUND Circulating tumor cells (CTCs) are associated with prognosis in a variety of human cancers and have been proposed as a liquid biopsy for follow-up examinations. We show that tumor suppressor and metastasis suppressor genes are epigenetically silenced in CTCs isolated from peripheral blood of breast cancer patients. METHODS We obtained peripheral blood from 56 patients with operable...

DNA methylation of tumor suppressor genes in hepatocellular carcinoma

The basic unit of chromatin is a nucleosome included an octamer of the four core histones and 147 base pairs of DNA. Posttranslational histones modifications affect chromatin structure resulting in gene expression changes. CpG islands hypermethylation within the gene promoter regions and the deacetylation of histone proteins are the most common epigenetic modifications. The aberrant patterns of...

Tumor suppressor genes.

Carcinogenesis is a multistep process in which cells accumulate multiple genetic alterations as they progress to a more malignant phenotype. Allelic chromosomal losses as well as mutations of tumor suppressor genes are common genetic events in the development and/or progression of both hereditary and non-hereditary tumors. Recent studies have shown a direct correlation between malignancy and in...

Tumor suppressor genes.